Structural Comparison of Ankyrin Repeat Domain of TRPV Channels
نویسندگان
چکیده
منابع مشابه
1 Structure of the N - Terminal Ankyrin Repeat Domain of the Trpv 2 Ion Channel
The TRPV ion channels mediate responses to many sensory stimuli including heat, low pH, neuropeptides and chemical ligands. All TRPV subfamily members contain an intracellular N-terminal ankyrin repeat domain (ARD) – a prevalent proteininteraction motif. The 1.6 Å crystal structure of the TRPV2-ARD, with six ankyrin repeats, reveals several atypical structural features. Repeats one through thre...
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Ankyrin repeat domain-encoding genes are common in the eukaryotic and viral domains of life, but they are rare in bacteria, the exception being a few obligate or facultative intracellular Proteobacteria species. Despite having a reduced genome, the arthropod strains of the alphaproteobacterium Wolbachia contain an unusually high number of ankyrin repeat domain-encoding genes ranging from 23 in ...
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The ankyrin repeat is one of the most common, modular, protein-protein interaction motifs in nature. To understand the structural determinants of this family of proteins and extract the consensus information that defines the architecture of this motif, we have designed a series of idealized ankyrin repeat proteins containing one, two, three, or four repeats by using statistical analysis of appr...
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ژورنال
عنوان ژورنال: Biophysical Journal
سال: 2011
ISSN: 0006-3495
DOI: 10.1016/j.bpj.2010.12.795